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Pillai 3 , S
The STEP 1 trial demonstrated that participants on semaglutide lost significantly more weight than placebo groups even at lower doses before escalation
Further studies to investigate this later possibility, including examination of the effect of GLP-1R in -cell lipid metabolism and mitochondrial nutrient utilisation under normal and glucolipotoxic stress conditions are warranted, as well as the investigation of the in vivo role of SPHKAP in GLP-1R-dependent glucoregulation
Subsequently, phase 1 and 2 studies were conducted, in which tirzepatide was compared to a placebo, and the outcomes were the efficacy and safety of tirzepatide and changes in baseline HbA1c after a few weeks
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